The 2020 WHO Classification of Tumors of Bone: An Updated Review.

@article{Choi2021The2W,
  title={The 2020 WHO Classification of Tumors of Bone: An Updated Review.},
  author={Joon Hyuk Choi and Jae Yun Ro},
  journal={Advances in Anatomic Pathology},
  year={2021}
}
  • J. Choi, J. Ro
  • Published 20 January 2021
  • Medicine
  • Advances in Anatomic Pathology
Bone tumors are a rare and heterogeneous group of neoplasms that occur in the bone. The diversity and considerable morphologic overlap of bone tumors with other mesenchymal and nonmesenchymal bone lesions can complicate diagnosis. Accurate histologic diagnosis is crucial for appropriate management and prognostication. Since the publication of the fourth edition of the World Health Organization (WHO) classification of tumors of soft tissue and bone in 2013, significant advances have been made in… 
Giant Cell Tumors of Bone in Patients Aged 18 Years Old or Younger: Imaging Features and Tumor Characteristics
TLDR
It is found that, in pediatric patients with GCTBs, the epiphysis is relatively less involved, and the tumor is more likely to grow longitudinally, helpful in the diagnosis of GCTB in the pediatric population.
Primary Bone Lymphoma: A Rare Cause of Chronic Back Pain
Primary bone lymphoma is a very uncommon malignancy, which is responsible for 3% of all bone tumors. We report a case of an 80-year-old patient with chronic back pain associated with a pathological
Update on the imaging features of the enchondromatosis syndromes
TLDR
The molecular genetics, pathology and multimodality imaging features of solitary enchondroma, Ollier disease and Maffucci syndrome, along with their associated skeletal complications, in particular secondary chondrosarcoma are outlined.
Osseous Tumor Reporting and Data System—Multireader Validation Study
TLDR
Osseous Tumor Reporting and Data System lexicon is reliable and helps stratify tumors into benign and malignant categories and can be practically used by radiologists to guide patient management, improve multidisciplinary communications, and potentially impact outcomes.
Pathogenesis and Current Treatment of Osteosarcoma: Perspectives for Future Therapies
TLDR
The role of normal bone biology in osteosarcomagenesis is discussed, highlighting the factors that drive normal osteoblast production, as well as abnormal osteOSarcoma development, and the development of novel therapeutics that encompass a series of molecular targets are explored.
Personalized chordoma organoids for drug discovery studies
TLDR
This proof-of-concept study successfully established organoids from seven chordoma tumor samples obtained from five patients presenting with tumors in different sites and stages of disease, and highlighted targeted agents such as PI3K/mTOR, EGFR, and JAK2/STAT3 inhibitors among the most effective molecules.
‘I Can’t Keep Up!’: an update on advances in soft tissue pathology occurring after the publication of the 2020 World Health Organization classification of soft tissue and bone tumours
TLDR
This review will attempt to summarise the developments in soft tissue pathology that have occurred since 2020, emphasising lesions for which morphology and genetics intersect in a complementary fashion.
Mutual Modulation Between Extracellular Vesicles and Mechanoenvironment in Bone Tumors
TLDR
The relationship between EVs and the mechanoenvironment during tumoral progression is summarized with the final aim to provide some innovative perspectives in counteracting bone cancers.
Tumor-like Lesions, unter besonderer Berücksichtigung der spinalen aneurysmatischen Knochenzyste
Die aneurysmatische Knochenzyste (AKZ) ist ein lokal aggressiv wachsender gutartiger primärer osteoklastischer Riesenzell-reicher Tumor, der in 10-30% die Wirbelsäule betrifft. Lange Zeit wurde
...
1
2
...

References

SHOWING 1-10 OF 234 REFERENCES
Primary vascular tumors of bone: a spectrum of entities?
TLDR
This review gives an overview of current literature by describing all different histologic subtypes in correspondence with clinical, radiologic and genetic data to propose the classification of vascular tumors of bone according to the three-tiered World Health Organization classification scheme for soft tissue tumors.
Histological and clinical characteristics of malignant giant cell tumor of bone
TLDR
MGCTB should be considered as a high-grade sarcoma and must be distinguished from GCTB and other malignant tumors containing giant cells, which might play a role in the malignant transformation of G CTB.
Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone
TLDR
Compared with de novo high-grade osteosarcoma or malignancies arising in GCT, tGCT showed less severe atypia, reduced mitotic activity, and lack of infiltrative growth pattern, but did not show a unique pattern of intralesional bone deposition.
Prognostic factors in chondrosarcoma of bone. A clinicopathologic analysis with emphasis on histologic grading
TLDR
It is concluded that chondrosarcomas range from locally aggressive non‐metastasizing neoplasms to high‐grade malignancies with marked metastatic potential, and that these groups may be defined and separated by the use of histopathologic criteria.
Dedifferentiated chondrosarcoma: the role of chemotherapy with updated outcomes.
TLDR
Despite advances in diagnostic modalities and adjuvant therapies, dedifferentiated chondrosarcoma continues to carry a poor prognosis and efforts are needed to continue to encourage earlier diagnosis and to develop effective adjUvant therapies for the control of distant disease.
Radiation-associated sarcoma of bone and soft tissue.
TLDR
Three variables had prognostic significance in multivariate analysis: the presence of metastatic disease, the completeness of operative resection in patients with localized disease, and the size of the primary tumor in patients who underwent complete resection of the sarcoma.
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor.
TLDR
A case arising in the left ischium of a 44-yr-old man with no previous history of radiation therapy or multiple resections, a typical giant cell tumor of bone juxtaposed to a malignant fibrous histiocytoma (MFH).
Epithelioid Hemangioma of Bone: A Tumor Often Mistaken for Low-Grade Angiosarcoma or Malignant Hemangioendothelioma
TLDR
It is believed that many of the vascular tumors of bone that have been reported as low-grade malignant hemangioendotheliomas probably represent examples of epithelioid hemangiomas, and the criteria for diagnosing vascular tumor of bone conform to those used for morphologically similar tumors that arise in the soft tissues.
...
1
2
3
4
5
...