The 2009 ESPEN Sir David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game?

@article{Cynober2010The2E,
  title={The 2009 ESPEN Sir David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game?},
  author={L. Cynober and C. Moinard and J. de Bandt},
  journal={Clinical nutrition},
  year={2010},
  volume={29 5},
  pages={
          545-51
        }
}
Citrulline (CIT) is synthesized from arginine (ARG) and glutamine in enterocytes and metabolized by the kidneys into arginine, which is available for peripheral tissues. Thus CIT, rather than ARG, could be a limiting amino acid (AA) in situations of intestinal failure. This was verified in a rat model of short bowel syndrome. The effects of CIT were further tested in renutrition of malnourished rats and in healthy volunteers fed a hypoproteic diet. CIT supplementation improved protein synthesis… Expand
Citrulline and nitrogen homeostasis: an overview
Is glutamine still an important precursor of citrulline?
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