The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes.

@article{Vardiman2009The2R,
  title={The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes.},
  author={James W. Vardiman and Juergen Thiele and Daniel A. Arber and Richard Brunning and Michael J. Borowitz and Anna Porwit and Nancy Lee Harris and Michelle M Le Beau and Eva Hellstr{\"o}m-Lindberg and Ayalew Tefferi and Clara Derber Bloomfield},
  journal={Blood},
  year={2009},
  volume={114 5},
  pages={
          937-51
        }
}
Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology, published a revised and updated edition of the WHO Classification of Tumors of the Hematopoietic and Lymphoid Tissues. The 4th edition of the WHO classification incorporates new information that has emerged from scientific and clinical studies in the interval since the publication of the 3rd edition in 2001, and includes new criteria for the… 
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Although therapy-related MDS and AML (t-MDS/AML) often have genetic defects identical to those found in de noVO AML and de novo MDS, they are classified separately from deNovo AMLand MDS in order to emphasize their unique clinical and biologic properties.
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The 2016 edition of the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues represents a revision of the prior classification rather than an entirely new classification and attempts to incorporate new clinical, prognostic, morphologic, immunophenotypic, and genetic data that have emerged since the last edition.
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World Health Organization Classification of tumors of hematopoietic and lymphoid tissues, 4th edition, 2008 – major changes from the 3rd edition, 2001*
The World Health Organization (WHO) classification of Tumors of Hematopoietic and Lymphoid Tissues (4th edition, 2008) represents an update of the 3rd edition, 2001.2 A summary of these changes in
Health Organization ( WHO ) classification of tumors of the ematopoietic and lymphoid tissues : An overview with emphasis n the myeloid neoplasms ames
TLDR
The aim of the revision was to incorporate new scientific and clinical information that has accumulated since the previous edition in order to refine diagnostic criteria for previously described neoplasms and to introduce newly recognized disease entities.
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