The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses.

@article{Wu2012The2H,
  title={The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses.},
  author={Wai Lan Wu and Siu-ying Lau and Yixin Chen and Genyan Wang and Bobo Wing-Yee Mok and Xi Wen and Pui Wang and Wenjun Song and Tianwei Lin and Kwok-hung Chan and Kwok-yung Yuen and Honglin Chen},
  journal={Antiviral research},
  year={2012},
  volume={93 1},
  pages={144-53}
}
A naturally-occurring H275Y oseltamivir resistant variant of influenza A (H1N1) virus emerged in 2007, subsequently becoming prevalent worldwide, via an undetermined mechanism. To understand the antigenic properties of the H275Y variant, oseltamivir resistant and susceptible strains of H1N1 viruses were analyzed by hemagglutination inhibition (HI) and microneutralization assays. HI analysis with H1-positive sera obtained from seasonal flu vaccine immunized and non-immunized individuals, and H1… CONTINUE READING