The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets.

@article{Bos1981The2K,
  title={The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets.},
  author={J. L. Bos and L J Polder and Ren{\'e} Bernards and Peter Schrier and Peter J. van den Elsen and Alex J van der Eb and Hans van Ormondt},
  journal={Cell},
  year={1981},
  volume={27 1 Pt 2},
  pages={121-31}
}
By nucleotide sequence analysis and S1 nuclease mapping we have determined the structural organization of early region E1b of Ad12. We have also revised the nucleotide sequence of the E1b region of Ad5. Both regions have an identical structural organization and show considerable homology at the nucleotide level. The major tumor antigens (Ad12, 19 and 54 kilodaltons [kd]); Ad5, 21 and 55 kd) are encoded in two overlapping reading frames. A single mRNA of 2.2 kilobases codes for both these… CONTINUE READING