The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans.

@article{Mande2015The2M,
  title={The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans.},
  author={Mette J Mand\oe and Katrine Bagge Hansen and Bolette Hartmann and Jens Frederik Rehfeld and Jens Juul Holst and Harald S Hansen},
  journal={The American journal of clinical nutrition},
  year={2015},
  volume={102 3},
  pages={548-55}
}
BACKGROUND Dietary triglycerides can, after digestion, stimulate the intestinal release of incretin hormones through activation of G protein-coupled receptor (GPR) 119 by 2-monoacylglycerol and by the activation of fatty acid receptors for long- and short-chain fatty acids. Medium-chain fatty acids do not stimulate the release of intestinal hormones. OBJECTIVE To dissect the mechanism of fat-induced glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) release… CONTINUE READING

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