The 2'-5'-oligoadenylate synthetase in the lowest metazoa: isolation, cloning, expression and functional activity in the sponge Lubomirskia baicalensis.

@article{Schrder2008The2S,
  title={The 2'-5'-oligoadenylate synthetase in the lowest metazoa: isolation, cloning, expression and functional activity in the sponge Lubomirskia baicalensis.},
  author={Heinz C. Schr{\"o}der and Filipe Natalio and Matthias Wiens and Muhammad Nawaz Tahir and Mohammed Ibrahim Shukoor and Wolfgang Tremel and Sergey I. Belikov and Anatoli Krasko and Werner E G M{\"u}ller},
  journal={Molecular immunology},
  year={2008},
  volume={45 4},
  pages={945-53}
}
Aquatic animals, especially filter feeders such as sponges [phylum Porifera], are exposed to a higher viral load than terrestrial species. Until now, the antiviral defense system in the evolutionary oldest multicellular organisms, sponges, is not understood. One powerful protection of vertebrates against virus infection is mediated by the interferon (IFN)-inducible 2'-5'-oligoadenylate synthetase [(2-5)A synthetase] system. In the present study we cloned from the freshwater sponge Lubomirskia… CONTINUE READING

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