The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.

@article{Wang2014The1D,
  title={The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.},
  author={Xin Wang and William C Stafford and Magdalena Mazurkiewicz and M{\aa}rten Frykn{\"a}s and Slavica Brjnic and Xiao-Nan Zhang and Joachim Gullbo and Rolf Larsson and Elias S J Arn{\'e}r and P{\'a}draig D'Arcy and Stig Linder},
  journal={Molecular pharmacology},
  year={2014},
  volume={85 6},
  pages={932-45}
}
b-AP15 [(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-(prop-2-enoyl)piperidin-4-one] is a small molecule inhibitor of the ubiquitin specific peptidase (USP) 14/ubiquitin carboxyl-terminal hydrolase (UCH) L5 deubiquitinases of the 19S proteasome that shows antitumor activity in a number of tumor models, including multiple myeloma. b-AP15 contains an… CONTINUE READING