The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.

@article{White1992The1A,
  title={The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.},
  author={E. P. White and Peter Sabbatini and M E Debbas and William S. M. Wold and David I. Kusher and Linda R. Gooding},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 6},
  pages={2570-80}
}
The adenovirus E1A and E1B proteins are required for transformation of primary rodent cells. When expressed in the absence of the 19,000-dalton (19K) E1B protein, however, the E1A proteins are acutely cytotoxic and induce host cell chromosomal DNA fragmentation and cytolysis, analogous to cells undergoing programmed cell death (apoptosis). E1A alone can efficiently initiate the formation of foci which subsequently undergo abortive transformation whereby stimulation of cell growth is… CONTINUE READING
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