The 185delAG BRCA1 mutation originated before the dispersion of Jews in the diaspora and is not limited to Ashkenazim.

@article{BarSade1998The1B,
  title={The 185delAG BRCA1 mutation originated before the dispersion of Jews in the diaspora and is not limited to Ashkenazim.},
  author={R B Bar-Sade and Anna Kruglikova and Baruch Modan and Eva Gak and Galit Hirsh-Yechezkel and Livia Theodor and Ilya B. Novikov and Ruth Gershoni-baruch and Shulamit Risel and Moshe Zvi Papa and Gilad Ben-Baruch and Eitan Friedman},
  journal={Human molecular genetics},
  year={1998},
  volume={7 5},
  pages={801-5}
}
The 185delAG mutation in BRCA1 is detected in Ashkenazi Jews both in familial breast and ovarian cancer and in the general population. All tested Ashkenazi mutation carriers share the same allelic pattern at the BRCA1 locus. Our previous study showed that this 'Ashkenazi' mutation also occurs in Iraqi Jews with a similar allelic pattern. We extended our analysis to other non-Ashkenazi subsets: 354 of Moroccan origin, 200 Yemenites and 150 Iranian Jews. Heteroduplex analysis complemented by… CONTINUE READING
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