The 17q23 Amplicon and Breast Cancer

  title={The 17q23 Amplicon and Breast Cancer},
  author={Colleen Schehl Sinclair and Matthew A Rowley and Ali M. Naderi and Fergus J. Couch},
  journal={Breast Cancer Research and Treatment},
A novel region of amplification in breast tumors was recently identified on chromosome 17q23. Extensive mapping of the amplicon by Southern blotting and fluorescence in situ hybridization (FISH) in breast cancer cell lines determined that the amplicon can be up to 4 Mbp in size and may contain 50 genes. Copy number analysis at 50–75 kb resolution in breast… CONTINUE READING