The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with peripheral artery occlusive disease.

@article{Flex2002TheG,
  title={The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with peripheral artery occlusive disease.},
  author={Andrea Flex and Eleonora Gaetani and Roberto Pola and Angelo Santoliquido and Francesco Aloi and Pierangelo Papaleo and Alessandro Dal Lago and Enrico Pola and Michele Serricchio and Paolo Tondi and Paolo Pola},
  journal={European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery},
  year={2002},
  volume={24 3},
  pages={264-8}
}
OBJECTIVE AND DESIGN high plasma levels of Interleukin-6 (IL-6) are found in patients with atherosclerotic disorders. Recently, a common polymorphism of the IL-6 gene promoter, influencing the transcription rate of the gene, has been described and associated with atherosclerosis of carotid and coronary arteries. The objective of this study was to test whether IL-6 gene promoter polymorphism is associated with peripheral artery occlusive disease (PAOD) in a case-control study. METHODS IL-6… CONTINUE READING

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