The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages.

@article{Yuan1998The1A,
  title={The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages.},
  author={Y Yuan and Deborah D. Crane and Robert Mark Simpson and Yong Qiang Zhu and Mark J. Hickey and David R. Sherman and Clifton E Barry},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 16},
  pages={9578-83}
}
Although the 16-kDa alpha-crystallin homologue of Mycobacterium tuberculosis (MTB) is the dominant protein produced by stationary phase cultures in vitro, it is undetectable in logarithmically growing cultures. By growing bacilli at defined oxygen concentrations, acr transcription was shown to be strongly induced by mildly hypoxic conditions. Acr expression also was found to be induced during the course of in vitro infection of macrophages. The acr gene was replaced with a hygromycin resistance… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 105 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Yuan et al

P. R. Meylan, D. D. Richman, Kornbluth, R. S. Am. Rev. Respir. Dis. 145, 947–953. Microbiology
Proc. Natl. Acad. Sci. USA 95 • 1998

Growth of H37Rv Dacr::hpt in vitro and in vivo

K. M. George, Y. Yuan, D. R. Sherman, C. E. Barry, III
J. Biol • 1995

Similar Papers

Loading similar papers…