The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema.

@article{Lambrechts2010The1S,
  title={The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema.},
  author={Diether Lambrechts and Ian Buysschaert and Pieter Zanen and Johan Coolen and Natacha Lays and Harry Cuppens and Harry J. M. Groen and Walter Dewever and Rob J. van Klaveren and Johny A. Verschakelen and Cisca Wijmenga and Dirkje S Postma and Marc Decramer and Wim Janssens},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={181 5},
  pages={486-93}
}
RATIONALE Genome-wide association studies have identified genetic variants in the nicotinic acetylcholine receptor (nAChR) on chromosome 15q24/25 as a risk for nicotine dependence, lung cancer, and chronic obstructive pulmonary disease (COPD). Assessment of bronchial obstruction by spirometry, typically used for diagnosing COPD, fails, however, to detect emphysema. OBJECTIVES To determine the association of the 15q24/25 locus with emphysema. METHODS The rs1051730 variant on 15q24/25 was… CONTINUE READING

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