The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.

@article{Shureiqi2003The1P,
  title={The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.},
  author={Imad Shureiqi and Wei Jiang and Xiangsheng Zuo and Yuanqing Wu and Julie B. Stimmel and Lisa M. Leesnitzer and Jeffrey S. Morris and Hui-zhen Fan and Susan M. Fischer and Scott Michael Lippman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 17},
  pages={9968-73}
}
Diminished apoptosis, a critical event in tumorigenesis, is linked to down-regulated 15-lipoxygenase-1 (15-LOX-1) expression in colorectal cancer cells. 13-S-hydroxyoctadecadienoic acid (13-S-HODE), which is the primary product of 15-LOX-1 metabolism of linoleic acid, restores apoptosis. Nonsteroidal antiinflammatory drugs (NSAIDs) transcriptionally up-regulate 15-LOX-1 expression to induce apoptosis. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for linoleic and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 90 extracted citations

Similar Papers

Loading similar papers…