The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.

Abstract

BACKGROUND & AIMS Childhood obesity is a growing problem worldwide. Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity in children. Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults. In this study we add further insight into the role of PNPLA3 by… (More)
DOI: 10.1016/j.jhep.2010.02.034

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