The 14 bp Del/Ins HLA-G Polymorphism Is Related with High Blood Pressure in Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Abstract

Immunologic and inflammatory processes are involved in the pathogenesis of acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM2). Human leukocyte antigen-G (HLA-G) is a negative regulator of the immune response. This study evaluates the 14 bp Del/Ins HLA-G polymorphism in ACS and DM2. Three hundred and seventy individuals from Western Mexico were recruited and categorized into three groups: ACS (86), DM2 without coronary complications (70), and healthy subjects (214). Genotyping of the 14 bp Del/Ins HLA-G polymorphism was performed by PCR and Native-PAGE. The most common risk factors were hypertension and overweight in ACS and DM2, respectively. The genetic distribution of the 14 bp Del/Ins HLA-G polymorphism showed no significant differences between groups (P ≥ 0.23). Nonetheless, the Ins/Ins genotype was associated with high blood pressure (HBP) in the DM2 group (OR(c) = 1.65, P = 0.02). The genetic recessive model showed similar findings (OR(c) = 3.03, P = 0.04). No association was found in ACS, with a P of 0.05; nevertheless, the prevalence of Ins/Ins carriers was quite similar to that found in the DM2-HBP group. The 14 bp Del/Ins HLA-G polymorphism was not a susceptibility factor for ACS or DM2; however, the Ins/Ins genotype might have contributed to the development of HBP in the studied groups.

DOI: 10.1155/2014/898159

Extracted Key Phrases

2 Figures and Tables

Cite this paper

@inproceedings{GarcaGonzlez2014The1B, title={The 14 bp Del/Ins HLA-G Polymorphism Is Related with High Blood Pressure in Acute Coronary Syndrome and Type 2 Diabetes Mellitus}, author={Ilian Janet Garc{\'i}a-Gonz{\'a}lez and Yeminia Valle and Fernando Rivas and Luis Eduardo Figuera-Villanueva and Jos{\'e} Francisco Mu{\~n}oz-Valle and Hector Enrique Flores-Salinas and Bianca Ethel Guti{\'e}rrez-Amavizca and Nory Omayra D{\'a}valos-Rodr{\'i}guez and Jorge Ram{\'o}n Padilla-Guti{\'e}rrez}, booktitle={BioMed research international}, year={2014} }