The 14-3-3 Protein Detectable in the Cerebrospinal Fluid of Patients with Prion-Unrelated Neurological Diseases Is Expressed Constitutively in Neurons and Glial Cells in Culture

@article{Satoh1999The1P,
  title={The 14-3-3 Protein Detectable in the Cerebrospinal Fluid of Patients with Prion-Unrelated Neurological Diseases Is Expressed Constitutively in Neurons and Glial Cells in Culture},
  author={J. Satoh and K. Kurohara and M. Yukitake and Y. Kuroda},
  journal={European Neurology},
  year={1999},
  volume={41},
  pages={216 - 225}
}
  • J. Satoh, K. Kurohara, +1 author Y. Kuroda
  • Published 1999
  • Biology, Medicine
  • European Neurology
  • The 14-3-3 protein belongs to a family of 30-kD proteins originally identified by two-dimensional analysis of brain protein extracts. Recently, the detection of the 14-3-3 protein in the cerebrospinal fluid (CSF) is utilized as a highly reliable test for the premortem diagnosis of prion diseases such as Creutzfeldt-Jakob disease. For the initial step, to clarify the biological implication of the CSF 14-3-3 protein in these diseases, its expression was investigated in neural tissues and cultures… CONTINUE READING
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