The 129 codon polymorphism of the Prion Protein gene influences earlier cognitive performance in Down syndrome subjects

@article{Bo2003The1C,
  title={The 129 codon polymorphism of the Prion Protein gene influences earlier cognitive performance in Down syndrome subjects},
  author={R. del Bo and G. Comi and R. Giorda and M. Crimi and F. Locatelli and F. Martinelli-Boneschi and U. Pozzoli and E. Castelli and N. Bresolin and G. Scarlato},
  journal={Journal of Neurology},
  year={2003},
  volume={250},
  pages={688-692}
}
  • R. del Bo, G. Comi, +7 authors G. Scarlato
  • Published 2003
  • Biology, Medicine
  • Journal of Neurology
    • Abstract. Recently, a frequent prion protein gene (PRNP) polymorphism consisting of a methionine (M) for valine (V) substitution at codon 129 has been associated with cognitive impairment in elderly individuals. Down syndrome (DS) is associated with mental retardation and development of Alzheimer-like brain abnormalities. In the present study, we investigated the role of the PRNP polymorphism in 122 relatively young Italian DS patients. Allele frequencies of DS subjects did not differ from… CONTINUE READING
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    References

    SHOWING 1-10 OF 24 REFERENCES
    Polymorphism of the prion protein is associated with cognitive impairment in the elderly
    • 75
    • Highly Influential
    Prion protein gene polymorphism and Alzheimer's disease: one modulatory trait of cognitive decline?
    • 34
    The apolipoprotein E ϵ4 allele causes a faster decline of cognitive performances in Down's syndrome subjects
    • 69
    Polymorphisms of the prion protein gene in Italian patients with Creutzfeldt-Jakob disease
    • 50
    Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD
    • 70
    Allelic variations in apolipoprotein E and prion protein genotype related to plaque formation and age of onset in sporadic Creutzfeldt-Jakob disease
    • 35
    The apolipoprotein E epsilon4 allele causes a faster decline of cognitive performances in Down's syndrome subjects.
    • 31
    Candidate Gene Association Studies in Sporadic Alzheimer’s Disease
    • 49
    APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome
    • 93
    Presenilin 1 and alpha-1-antichymotrypsin polymorphisms in Down syndrome: no effect on the presence of dementia.
    • 7