The 1239G/C polymorphism in exon 5 of BACE1 gene may be associated with sporadic Alzheimer's disease in Chinese Hans.

@article{Shi2004The1P,
  title={The 1239G/C polymorphism in exon 5 of BACE1 gene may be associated with sporadic Alzheimer's disease in Chinese Hans.},
  author={Jiajun Shi and Sizhong Zhang and Mouni Tang and Xiehe Liu and Tao Li and Yingcheng Wang and Haiying Han and Yangbo Guo and Yuantao Hao and Keqin Zheng and Xiangdong Kong and Zhiguang Su and Yu Neng Tong and Cui Ying Ma},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2004},
  volume={124B 1},
  pages={
          54-7
        }
}
Beta-site amyloid-precursor protein cleaving enzyme (BACE1) is a candidate risk factor for Alzheimer's disease (AD) because of involving in generating beta-amyloid peptide, which is thought to play a central role in the pathogenesis of the disease. A single nucleotide polymorphism 1239G/C in exon 5 of BACE1 gene and a weak association between this polymorphism and AD in Caucasian APOEepsilon4 allele carriers has been reported. To examine possible association of the polymorphism with sporadic AD… CONTINUE READING
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