The 12-month efficacy and safety of insulin detemir and NPH insulin in basal-bolus therapy for the treatment of type 1 diabetes.

@article{Standl2004The1E,
  title={The 12-month efficacy and safety of insulin detemir and NPH insulin in basal-bolus therapy for the treatment of type 1 diabetes.},
  author={Eberhard Standl and H. -G. Lang and A. D. Roberts},
  journal={Diabetes technology & therapeutics},
  year={2004},
  volume={6 5},
  pages={579-88}
}
BACKGROUND This trial compared the long-term safety and efficacy of the basal insulin preparations, insulin detemir and NPH insulin, in basal-bolus therapy for patients with type 1 diabetes. METHODS This multinational open, parallel-group trial randomized patients to receive insulin detemir or NPH insulin twice daily in addition to mealtime human soluble insulin. Doses were titrated towards predefined glycemic targets. After an initial 6-month treatment period, patients were invited to… CONTINUE READING