The -106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes.

@article{Santos2006TheG,
  title={The -106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes.},
  author={K{\'a}tia Gonçalves dos Santos and Luis Henrique Santos Canani and Jorge Luiz Gross and Baldu{\'i}no Tschiedel and K{\'a}tia Elisabete Pires Souto and Israel Roisenberg},
  journal={Molecular genetics and metabolism},
  year={2006},
  volume={88 3},
  pages={280-4}
}
Diabetic retinopathy is a sight-threatening chronic complication of diabetes mellitus and is the leading cause of acquired blindness in adults. The -106C>T polymorphism in the promoter region of the aldose reductase (AR) gene has been shown to be associated with the susceptibility to diabetic nephropathy in type 2 diabetes, but the findings regarding the occurrence of diabetic retinopathy are conflicting. In this case-control study, we investigated whether the -106C>T polymorphism in the AR… CONTINUE READING
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