The 1,4-dihydropyridine nucleus: a pharmacophoric template part 1. Actions at ion channels.

@article{Triggle2003The1N,
  title={The 1,4-dihydropyridine nucleus: a pharmacophoric template part 1. Actions at ion channels.},
  author={David J. Triggle},
  journal={Mini reviews in medicinal chemistry},
  year={2003},
  volume={3 3},
  pages={215-23}
}
The 1,4-dihydropyridine nifedipine is a prototypical example of the group of calcium channel blockers that also includes a number of second and third generation agents. These drugs enjoy substantial therapeutic prominence for their cardiovascular actions, including hypertension and angina. These actions are exerted at a specific member of the voltage-gated calcium channel family -the L-type channel. However, it is increasingly clear that the 1,4-dihydropyridine structure is a pharmacophoric… CONTINUE READING

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