The −174/−597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis

@article{Fedetz2001TheP,
  title={The −174/−597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis},
  author={Marı́a Fedetz and Fuencisla Matesanz and Mercedes Fern{\'a}ndez Pascual and Judy K Martin and Oscar Fern{\'a}ndez and Miguel {\'A}ngel V{\'a}zquez Guerrero and Antonio Alcina},
  journal={Journal of the Neurological Sciences},
  year={2001},
  volume={190},
  pages={69-72}
}
Interleukin-6 (IL-6) has been implicated in the etiology of experimental autoimmune encephalomyelitis (EAE) in transgenic animals and contributes to neuropathology in humans. A single nucleotide polymorphism (SNP) at position -174 in the IL-6 gene promoter (IL-6pr) appears to influence IL-6 expression. Complete linkage disequilibrium was observed between the -174 and the -597 alleles. The aim of this study was to investigate the possible influence of -174/-597 IL-6pr polymorphisms on… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Similar Papers

Loading similar papers…