The “old drug” dacarbazine as a second/third line chemotherapy in advanced soft tissue sarcomas

@article{Zucali2007TheD,
  title={The “old drug” dacarbazine as a second/third line chemotherapy in advanced soft tissue sarcomas},
  author={Paolo Andrea Zucali and Alexia Bertuzzi and Hector Jos{\`e} Soto Parra and Elisabetta Campagnoli and Vittorio Quagliuolo and Armando Santoro},
  journal={Investigational New Drugs},
  year={2007},
  volume={26},
  pages={175-181}
}
The aim of this study was to evaluate retrospectively the response rate, progression-free survival and median duration of response to dacarbazine as second/third-line chemotherapy for refractory soft tissue sarcomas. We studied 40 valuable patients with refractory soft tissue sarcomas and confirmed progressive disease (median age 54 years; range 24–73) treated between May 1997 and October 2005: 30 (75%) with metastases, and 23 (57.5%) with grade 3 disease. Dacarbazine was given as second-line… CONTINUE READING

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