The “Steroid Dementia Syndrome”: A Possible Model of Human Glucocorticoid Neurotoxicity

@article{Wolkowitz2007TheD,
  title={The “Steroid Dementia Syndrome”: A Possible Model of Human Glucocorticoid Neurotoxicity},
  author={O. Wolkowitz and S. Lupien and E. Bigler},
  journal={Neurocase},
  year={2007},
  volume={13},
  pages={189 - 200}
}
  • O. Wolkowitz, S. Lupien, E. Bigler
  • Published 2007
  • Psychology, Medicine
  • Neurocase
    • Glucocorticoid medications cause neurotoxicity in animals under certain circumstances, but it is not known if this occurs in humans. We present the case of a 10-year-old boy with no prior psychiatric history and no prior exposure to glucocorticoid medication who received a single 5-week course of glucocorticoids for an acute asthma flare. Beginning during steroid treatment, and persisting for over 3 years after stopping treatment, he showed a significant decline from his pre-morbid academic… CONTINUE READING
    View on Taylor & Francis
    ncbi.nlm.nih.gov
    38 Citations
    Background Citations
    14
    Results Citations
    1
    38 Citations
    Citation Type

    Citation Type

    Behavioral, Psychiatric, and Cognitive Adverse Events in Older Persons Treated with Glucocorticoids
    • 5
    • PDF
    Glucocorticoids. Mood, memory, and mechanisms.
    • 140
    Glucocorticoids
    Glucocorticoid Dysregulations and Their Clinical Correlates
    • 120
    A Systematic Review of the Neuropsychological Sequelae of People Diagnosed with Anti N-Methyl-D-Aspartate Receptor Encephalitis in the Acute and Chronic Phases
    • D. M. Nicolle, J. Moses
    • Medicine
    • Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
    • 2018
    • 6
    Neuropsychiatric findings in Cushing syndrome and exogenous glucocorticoid administration.
    • M. Starkman
    • Medicine
    • Endocrinology and metabolism clinics of North America
    • 2013
    • 49
    Major Depression Cortisol Abnormalities in Major Depression Cortisol ’ s relationship to psychiatric illness
    • PDF
    Steroid and nonsteroidal anti-inflammatory drugs, cognitive decline, and dementia
    • 21
    • PDF
    Mathematical processing is affected by daily but not cumulative glucocorticoid dose in patients with systemic lupus erythematosus.
    • 2
    • PDF
    Central nervous system effects of natural and synthetic glucocorticoids
    • 86

    References

    SHOWING 1-10 OF 79 REFERENCES
    Glucocorticoid Medication, Memory and Steroid Psychosis in Medical Illness
    • 140
    [Cognitive impairment after accidental high-dose corticosteroid therapy].
    • 8
    Do Glucocorticoids Have Adverse Effects on Brain Function?
    • 13
    A case of reversible steroid dementia.
    • N. Varney
    • Psychology, Medicine
    • Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
    • 1997
    • 11
    • PDF
    Steroid-induced psychiatric syndromes. A report of 14 cases and a review of the literature.
    • 408
    • PDF
    Presentation of the Steroid Psychoses
    • 313
    Commonly Used Therapeutic Doses of Glucocorticoids Impair Explicit Memory
    • 53
    Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome.
    • 108
    • PDF
    Reversible steroid dementia in patients without steroid psychosis.
    • 148
    Reversible dementia with parkinsonian features associated with budesonide use
    • 6