The “Steroid Dementia Syndrome”: A Possible Model of Human Glucocorticoid Neurotoxicity
@article{Wolkowitz2007TheD, title={The “Steroid Dementia Syndrome”: A Possible Model of Human Glucocorticoid Neurotoxicity}, author={O. Wolkowitz and S. Lupien and E. Bigler}, journal={Neurocase}, year={2007}, volume={13}, pages={189 - 200} }
Glucocorticoid medications cause neurotoxicity in animals under certain circumstances, but it is not known if this occurs in humans. We present the case of a 10-year-old boy with no prior psychiatric history and no prior exposure to glucocorticoid medication who received a single 5-week course of glucocorticoids for an acute asthma flare. Beginning during steroid treatment, and persisting for over 3 years after stopping treatment, he showed a significant decline from his pre-morbid academic… CONTINUE READING
Topics from this paper
38 Citations
Behavioral, Psychiatric, and Cognitive Adverse Events in Older Persons Treated with Glucocorticoids
- Medicine
- Medicines
- 2018
- 5
- PDF
Glucocorticoids. Mood, memory, and mechanisms.
- Psychology, Medicine
- Annals of the New York Academy of Sciences
- 2009
- 140
Glucocorticoid Dysregulations and Their Clinical Correlates
- Psychology, Medicine
- Annals of the New York Academy of Sciences
- 2009
- 120
A Systematic Review of the Neuropsychological Sequelae of People Diagnosed with Anti N-Methyl-D-Aspartate Receptor Encephalitis in the Acute and Chronic Phases
- Medicine
- Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
- 2018
- 6
Neuropsychiatric findings in Cushing syndrome and exogenous glucocorticoid administration.
- Medicine
- Endocrinology and metabolism clinics of North America
- 2013
- 49
Steroid and nonsteroidal anti-inflammatory drugs, cognitive decline, and dementia
- Medicine
- Neurobiology of Aging
- 2012
- 21
- PDF
Mathematical processing is affected by daily but not cumulative glucocorticoid dose in patients with systemic lupus erythematosus.
- Medicine
- Rheumatology
- 2020
- 2
- PDF
Central nervous system effects of natural and synthetic glucocorticoids
- Psychology, Medicine
- Psychiatry and clinical neurosciences
- 2009
- 86
References
SHOWING 1-10 OF 79 REFERENCES
Glucocorticoid Medication, Memory and Steroid Psychosis in Medical Illness
- Medicine
- Annals of the New York Academy of Sciences
- 1997
- 140
[Cognitive impairment after accidental high-dose corticosteroid therapy].
- Medicine
- Der Nervenarzt
- 2004
- 8
A case of reversible steroid dementia.
- Psychology, Medicine
- Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
- 1997
- 11
- PDF
Steroid-induced psychiatric syndromes. A report of 14 cases and a review of the literature.
- Medicine
- Journal of affective disorders
- 1983
- 408
- PDF
Commonly Used Therapeutic Doses of Glucocorticoids Impair Explicit Memory
- Medicine
- Annals of the New York Academy of Sciences
- 1995
- 53
Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome.
- Medicine
- The Journal of clinical endocrinology and metabolism
- 2005
- 108
- PDF
Reversible steroid dementia in patients without steroid psychosis.
- Medicine
- The American journal of psychiatry
- 1984
- 148