The “Glutamate Switch” : a link between ATPase activity and ligand binding in AAA+ proteins

@inproceedings{Zhang2008TheS,
  title={The “Glutamate Switch” : a link between ATPase activity and ligand binding in AAA+ proteins},
  author={Xiaodong Zhang and Dale B. Wigley},
  booktitle={Nature Structural &Molecular Biology},
  year={2008}
}
AAA+ proteins carry out diverse functions in cells. In most cases, their ATPase activity is tightly regulated by protein partners and target ligands, but the mechanism for this control has remained unclear. We have identified a conserved link between the ligand binding and ATPase sites in AAA+ proteins. This link, which we call the 'glutamate switch', regulates ATPase activity directly in response to the binding of target ligands by controlling the orientation of the conserved glutamate residue… CONTINUE READING

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