The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.

@article{Balducci2011TheM,
  title={The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.},
  author={Claudia Balducci and Bisan Al Mehdawy and Lydia Mare and Alessandro Giuliani and Luca Lorenzini and Sandra Sivilia and Luciana Giardino and Laura Calz{\`a} and Annamaria Lanzillotta and Ilenia Sarnico and Marina Pizzi and Alessandro Usiello and Arturo Roberto Viscomi and Simone Ottonello and Gino Villetti and Bruno Pietro Imbimbo and Giuseppe Nistic{\'o} and Gianluigi Forloni and Robert Nistic{\`o}},
  journal={Journal of Alzheimer's disease : JAD},
  year={2011},
  volume={24 4},
  pages={
          799-816
        }
}
Abnormal amyloid-β (Aβ) production and deposition is believed to represent one of the main causes of Alzheimer's disease (AD). γ-Secretase is the enzymatic complex responsible for Aβ generation from its precursor protein. Inhibition or modulation of γ-secretase represents an attractive therapeutic approach. CHF5074 is a new γ-secretase modulator that has been shown to inhibit brain plaque deposition and to attenuate memory deficit in adult AD transgenic mice after chronic treatment. To date, it… CONTINUE READING
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