The β3-adrenoceptor agonist SR58611A inhibits gastric acid secretion in the conscious cat

The effect of the β3-adrenoceptor agonist {N-[(2S)-7-ethoxycarbonyl-methoxyl-1, 2, 3, 4-tetrahydro-naphth-2-yl] (2R)-2-(3-chloro-phenyl)2-hydroxyethanamine hydrochloride} (SR58611A) on gastric acid secretion was investigated in conscious cats with a gastric fistula. Intravenous infusion of SR58611A (0.3–3μmol/kg/h) caused a dose-dependent inhibition of the… (More)