The β2-microglobulin gene is on chromosome 15 and not in the HL-A region

@article{Goodfellow1975TheG,
  title={The β2-microglobulin gene is on chromosome 15 and not in the HL-A region},
  author={Peter N. Goodfellow and Elizabeth A.V. Jones and Veronica van Heyningen and E. Solomon and Martin Bobrow and V C Miggiano and Walter F. Bodmer},
  journal={Nature},
  year={1975},
  volume={254},
  pages={267-269}
}
POSSIBLE evolutionary homology between the genetic regions controlling histocompatibility antigens (such as HL-A in man and H-2 in the mouse) and immunoglobulins has been proposed1,2. Recent studies involving β2-microglobulin (β2m) seem to support this idea. Human β2m was found originally in the urine of patients with renal tubular dysfunction. It is also… CONTINUE READING