The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

@article{Hall1998TheR,
  title={The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange},
  author={Randy A Hall and Richard T Premont and C A Chow and Jeremy T. Blitzer and Julie A. Pitcher and Audrey Claing and Robert H. Stoffel and Larry S Barak and Shirish S Shenolikar and Edward J. Weinman and Sergio Grinstein and Robert J Lefkowitz},
  journal={Nature},
  year={1998},
  volume={392},
  pages={626-630}
}
Stimulation of β2-adrenergic receptors on the cell surface by adrenaline or noradrenaline leads to alterations in the metabolism, excitability, differentiation and growth of many cell types. These effects have traditionally been thought to be mediated exclusively by receptor activation of intracellular G proteins. However, certain physiological effects of β2-adrenergic receptor stimulation, notably the regulation of cellular pH by modulation of Na+/H+ exchanger (NHE) function, do not seem to be… CONTINUE READING
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