The β1 Subunit Enhances Oxidative Regulation of Large-Conductance Calcium-activated K+ Channels

@article{Santarelli2004TheS,
  title={The β1 Subunit Enhances Oxidative Regulation of Large-Conductance Calcium-activated K+ Channels},
  author={Lindsey Ciali Santarelli and Jianguo Chen and Stefan H. Heinemann and Toshinori Hoshi},
  journal={The Journal of General Physiology},
  year={2004},
  volume={124},
  pages={357 - 370}
}
Oxidative stress may alter the functions of many proteins including the Slo1 large conductance calcium-activated potassium channel (BKCa). Previous results demonstrated that in the virtual absence of Ca2+, the oxidant chloramine-T (Ch-T), without the involvement of cysteine oxidation, increases the open probability and slows the deactivation of BKCa channels formed by human Slo1 (hSlo1) alpha subunits alone. Because native BKCa channel complexes may include the auxiliary subunit beta1, we… CONTINUE READING