The β-catenin destruction complex.

  title={The β-catenin destruction complex.},
  author={Jennifer L. Stamos and William I Weis},
  journal={Cold Spring Harbor perspectives in biology},
  volume={5 1},
The Wnt/β-catenin pathway is highly regulated to insure the correct temporal and spatial activation of its target genes. In the absence of a Wnt stimulus, the transcriptional coactivator β-catenin is degraded by a multiprotein "destruction complex" that includes the tumor suppressors Axin and adenomatous polyposis coli (APC), the Ser/Thr kinases GSK-3 and CK1, protein phosphatase 2A (PP2A), and the E3-ubiquitin ligase β-TrCP. The complex generates a β-TrCP recognition site by phosphorylation of… CONTINUE READING
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