The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

  title={The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates},
  author={H. Choe and M. Farzan and Ying Sun and N. Sullivan and B. Rollins and P. Ponath and L. Wu and C. Mackay and G. Larosa and W. Newman and N. Gerard and Craig J. Gerard and J. Sodroski},
  • H. Choe, M. Farzan, +10 authors J. Sodroski
  • Published 1996
  • Biology, Medicine
  • Cell
  • We examined the ability of chemokine receptors and related G protein-coupled receptors to facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be infected. CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibited infection by these isolates. Utilization of CCR3 and CCR5 on the target cell depended upon… CONTINUE READING
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