The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors.

  title={The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors.},
  author={Jeffrey S Smith and Sudarshan Rajagopal},
  journal={The Journal of biological chemistry},
  volume={291 17},
The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion, βarrs adopt multiple conformations and are regulated at multiple levels to differentially activate downstream pathways. Recent structural studies have demonstrated that βarrs have a conserved structure and activation mechanism, with plasticity… CONTINUE READING
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