The β‐Amyloid Precursor Protein (APP) and Alzheimer's Disease: Does the Tail Wag the Dog?

@article{Koo2002TheP,
  title={The $\beta$‐Amyloid Precursor Protein (APP) and Alzheimer's Disease: Does the Tail Wag the Dog?},
  author={Edward H. Koo},
  journal={Traffic},
  year={2002},
  volume={3}
}
  • E. Koo
  • Published 1 September 2002
  • Biology, Chemistry
  • Traffic
The β‐amyloid precursor protein has been the focus of much attention from the Alzheimer's disease community for the past decade and a half. The β‐amyloid precursor protein holds a pivotal position in Alzheimer's disease research because it is the precursor to the amyloid β‐protein which many believe plays a central role in Alzheimer's disease pathogenesis. It was also the first gene in which mutations associated with inherited Alzheimer's disease were found. Although the molecular details of… 

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