The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.


Allergic asthma is the most common form of asthma, affecting more than 10 million Americans. Although it is clear that mast cells have a key role in the pathogenesis of allergic asthma, the mechanisms by which they regulate airway narrowing in vivo remain to be elucidated. Here we report that mice lacking αvβ6 integrin are protected from exaggerated airway… (More)
DOI: 10.1172/JCI58815


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