The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse.

Abstract

The 15q25 gene cluster contains genes that code for the α5, α3, and β4 nicotinic acetylcholine receptor (nAChRs) subunits, and in human genetic studies, has shown the most robust association with smoking behavior and nicotine dependence to date. The limited available animal studies implicate a role for the α5 and β4 nAChR subunits in nicotine dependence and… (More)
DOI: 10.1016/j.neuropharm.2013.01.017

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Cite this paper

@article{Jackson2013TheN, title={The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse.}, author={Kia J. Jackson and Sarah S. Sanjakdar and Pretal P. Muldoon and John Michael McIntosh and Mohamad Imad Damaj}, journal={Neuropharmacology}, year={2013}, volume={70}, pages={228-35} }