The α2β1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines

@article{Grzesiak2006TheI,
  title={The α2β1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines},
  author={John J Grzesiak and Michael Bouvet},
  journal={British Journal of Cancer},
  year={2006},
  volume={94},
  pages={1311 - 1319}
}
Pancreatic cancer is characterised by a hallmark desmoplastic response that includes upregulated expression of the extracellular matrix, and type I collagen in particular. Recent studies indicate that pancreatic cancer cells stimulate type I collagen synthesis in adjacent stellate cells, and that this upregulated type I collagen expression promotes the malignant phenotype in tumour cells as defined by increased proliferation, resistance to chemically induced apoptosis, and increased… CONTINUE READING