The α1-adrenergic receptors: diversity of signaling networks and regulation

  title={The α1-adrenergic receptors: diversity of signaling networks and regulation},
  author={Susanna Cotecchia},
  booktitle={Journal of receptor and signal transduction research},
The α(1)-adrenergic receptor (AR) subtypes (α(1a), α(1b), and α(1d)) mediate several physiological effects of epinephrine and norepinephrine. Despite several studies in recombinant systems and insight from genetically modified mice, our understanding of the physiological relevance and specificity of the α(1)-AR subtypes is still limited. Constitutive activity and receptor oligomerization have emerged as potential features regulating receptor function. Another recent paradigm is that β arrestins… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 23 extracted citations

Alpha 1-Adrenergic Receptor Activation Stimulates Calcium Entry and Proliferation via TRPC 6 Channels in Cultured Human Mesangial Cells

Fanwu Konga Linlin Maa Li Zoua Kexin Menga Tianrong Jia Zhanga, Rui Zhanga Jundong Jiaoa


Publications referenced by this paper.
Showing 1-10 of 57 references

Fine-tuning of GPCR activity by receptor-interacting proteins

Nature Reviews Molecular Cell Biology • 2009
View 2 Excerpts

Direct interaction of ezrin with the alpha1b-adrenergic receptor regulates recycling of the internalized receptors

L Stanasila, L Abuin, D Diviani, S. Cotecchia
J Biol Chem • 2006
View 2 Excerpts

Similar Papers

Loading similar papers…