The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat.

@article{Bassett2011TheA,
  title={The $\alpha$-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat.},
  author={Chantal M. C. Bassett and Richelle S. McCullough and Andrea L. Edel and Amanda F Patenaude and Ren{\'e}e K. LaVall{\'e}e and Grant N Pierce},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={301 6},
  pages={
          H2220-6
        }
}
Dietary intake of industrially hydrogenated trans fatty acids (TFA) has been associated with coronary heart disease. Dietary flaxseed can inhibit atherosclerosis induced by dietary cholesterol. The aim of this study was to determine whether supplementing the diet with flaxseed could protect against atherosclerosis induced by a diet enriched in TFA. Low-density lipoprotein receptor-deficient (LDLr(-/-)) mice were fed 1 of 14 experimental diets for 14 wk containing one of two fat sources [regular… 
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References

SHOWING 1-10 OF 52 REFERENCES

Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice.

It is found that consuming a hydrogenated elaidic acid-rich diet stimulates atherosclerosis, whereas a vaccenic acid- rich butter protects against atherosclerotic plaque formation in this animal model.

Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions.

It is demonstrated that dietary flaxseed can inhibit atherosclerosis in the LDLrKO mouse through a reduction of circulating cholesterol levels and, at a cellular level, via antiproliferative and anti-inflammatory actions.

Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients

A hypotensive effect of ALA is observed, which may constitute another mechanism accounting in part for the apparent cardioprotective effect of this n−3 fatty acid.

Trans-fatty acids in the diet stimulate atherosclerosis.

The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid.

Effects of dietary flaxseed on vascular contractile function and atherosclerosis during prolonged hypercholesterolemia in rabbits.

Dietary flaxseed is a valuable strategy to limit cholesterol-induced atherogenesis as well as abnormalities in endothelial-dependent vasorelaxation, however, these beneficial effects were attenuated during prolonged hypercholesterolemic conditions.

Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid.

Flaxseed supplementation in hyperlipidemic patients.

Investigation of the effect of daily consumption of dietary flaxseed on plasma lipid concentrations in mildly hyperlipidemic patients found it significantly improves lipid profile in hyperlipIDemic patients and may favorably modify cardiovascular risk factors.

Dietary n-3 polyunsaturated fatty acids prevent the development of atherosclerotic lesions in mice. Modulation of macrophage secretory activities.

Interestingly, a progressive increase of the LPS-induced IL-1 beta gene expression and secretion among macrophages harvested from mice receiving the dietary supplement of saturated fatty acids is observed.

Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women.

The results of the present study indicate that Native American postmenopausal women benefit from regular consumption of flaxseed by reducing their risk of cardiovascular disease as seen from lowered LDL-C and total cholesterol levels.
...