# The α-helix dipole and the properties of proteins

@article{Hol1978TheD,
title={The $\alpha$-helix dipole and the properties of proteins},
author={Wim G. J. Hol and P. T. van Duijnen and H. J. C. Berendsen},
journal={Nature},
year={1978},
volume={273},
pages={443-446}
}
• Published 1978
• Chemistry
• Nature
Phosphate moieties bind frequently at N-termini of helices in proteins. It is shown that this corresponds with an optimal interaction of the helix dipole and the charged phosphate. This favourable arrangement may have been discovered several times during evolution. In some enzymes, the helix dipole might be used in catalysis.
817 Citations
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• 1981
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• 1988
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• Biology, Medicine
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