The α-aminoadipate pathway for lysine biosynthesis in fungi

@article{Xu2006TheP,
  title={The $\alpha$-aminoadipate pathway for lysine biosynthesis in fungi},
  author={Hengyu Xu and Babak Andi and Jinghua Qian and Ann H West and Paul F. Cook},
  journal={Cell Biochemistry and Biophysics},
  year={2006},
  volume={46},
  pages={43-64}
}
This review provides a description of the biochemistry and enzymology of the α-aminoadipate pathway for lysine biosynthesis in fungi. The α-aminoadipate pathway is unique to fungi and is thus a potential target for the rational design of antifungal drugs. The present state of knowledge of the mechanisms of the seven enzymes in the pathway is presented, as well as detailed information with respect to structures and mechanisms of homocitrate synthase, saccharopine reductase, and saccharopine… 
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The crystal structure of HCS complexed with lysine showed that Lysine is bound to the active site with rearrangement of amino acid residues in the substrate-binding site, which accounts for the competitive inhibition by lysines with α-KG.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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