The [Het-s] Prion, an Amyloid Fold as a Cell Death Activation Trigger

@inproceedings{Saupe2012TheP,
  title={The [Het-s] Prion, an Amyloid Fold as a Cell Death Activation Trigger},
  author={Sven J. Saupe and Asen Daskalov},
  booktitle={PLoS pathogens},
  year={2012}
}
Prions are self-propagating amyloids. Amyloids are protein polymers with a cross-b structure, in which short b-strands from the monomers stack one on top of each other to make up a fibrillar polymer [1,2]. These amyloids act as templates that convert monomers to the amyloid polymerised state. Spontaneous or chaperone-assisted fragmentation of this amyloid fibril allows multiplication of the prion particle by generating novel fibril ends where templating occurs. Prions have initially been… CONTINUE READING
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