The (pro)renin receptor and its interaction partners

@article{Peters2017TheR,
  title={The (pro)renin receptor and its interaction partners},
  author={J{\"o}rg Peters},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2017},
  volume={469},
  pages={1245-1256}
}
The prorenin receptor was originally discovered as a receptor that binds renin and prorenin, thereby inducing pro-fibrotic intracellular signal cascades. These effects are partially mediated in vitro by angiotensin (ANG) and partially independent of ANG. Consequently, inhibitors of the interaction between the prorenin and the (pro)renin receptor (PRR) were designed hoping that they may prevent fibrotic tissue damage, for instance, in the kidney. However, this concept was challenged by the fact… CONTINUE READING