The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes.

@article{Kinouchi2010TheR,
  title={The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes.},
  author={Kenichiro Kinouchi and Atsuhiro Ichihara and Motoaki Sano and Ge-hong Sun-Wada and Yoh Wada and Asako Kurauchi-Mito and Kanako Bokuda and Tatsuya Narita and Yoichi Oshima and Mariyo Sakoda and Yoshitaka Tamai and Hiromu Sato and Keiichi Fukuda and Hiroshi Itoh},
  journal={Circulation research},
  year={2010},
  volume={107 1},
  pages={30-4}
}
RATIONALE The (pro)renin receptor [(P)RR], encoded in ATP6AP2, plays a key role in the activation of local renin-angiotensin system (RAS). A truncated form of (P)RR, termed M8.9, was also found to be associated with the vacuolar H(+)-ATPase (V-ATPase), implicating a non-RAS-related function of ATP6AP2. OBJECTIVE We investigated the role of (P)RR/ATP6AP2 in murine cardiomyocytes. METHODS AND RESULTS Cardiomyocyte-specific ablation of Atp6ap2 resulted in lethal heart failure; the… CONTINUE READING
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