The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants

  title={The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants},
  author={Jo{\~a}o Fadista and Alisa Knodle Manning and Jose C Florez and Leif Groop},
  journal={European Journal of Human Genetics},
Genome-wide association studies (GWAS) have long relied on proposed statistical significance thresholds to be able to differentiate true positives from false positives. Although the genome-wide significance P-value threshold of 5 × 10−8 has become a standard for common-variant GWAS, it has not been updated to cope with the lower allele frequency spectrum used in many recent array-based GWAS studies and sequencing studies. Using a whole-genome- and -exome-sequencing data set of 2875 individuals… CONTINUE READING
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