The 'short' history of regulatory B cells.

  title={The 'short' history of regulatory B cells.},
  author={C Mauri and Michael R. Ehrenstein},
  journal={Trends in immunology},
  volume={29 1},
The maintenance of tolerance is the sine qua non of a sophisticated regulatory apparatus to prevent or dampen overzealous immune responses. In addition to the ability of B cells to prime and activate the immune system, B cells with regulatory function (Bregs) have been identified in experimental models of autoimmunity, infections, and cancer, supporting the notion that, similar to regulatory T cells (Tregs), Breg-mediated suppression is an important means for the maintenance of peripheral… CONTINUE READING

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