The 'resting-state hypothesis' of major depressive disorder-a translational subcortical-cortical framework for a system disorder.

@article{Northoff2011TheH,
  title={The 'resting-state hypothesis' of major depressive disorder-a translational subcortical-cortical framework for a system disorder.},
  author={Georg Northoff and Christine Wiebking and Todd E. Feinberg and Jaak Panksepp},
  journal={Neuroscience and biobehavioral reviews},
  year={2011},
  volume={35 9},
  pages={1929-45}
}
Major depressive disorder (MDD) has traditionally been characterized by various psychological symptoms, involvement of diverse functional systems (e.g., somatic, affect, cognition, reward, etc.), and with progress in neuroscience, an increasing number of brain regions. This has led to the general assumption that MDD is a stress-responsive brain 'system disorder' where either one or several alterations infiltrate a large number of functional systems in the brain that control the organism's… CONTINUE READING

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