The 'polysemous' codon--a codon with multiple amino acid assignment caused by dual specificity of tRNA identity.

@article{Suzuki1997TheC,
  title={The 'polysemous' codon--a codon with multiple amino acid assignment caused by dual specificity of tRNA identity.},
  author={Tsutomu Suzuki and Takuya Ueda and Kimitsuna Watanabe},
  journal={The EMBO journal},
  year={1997},
  volume={16 5},
  pages={1122-34}
}
In some Candida species, the universal CUG leucine codon is translated as serine. However, in most cases, the serine tRNAs responsible for this non-universal decoding (tRNA(Ser)CAG) accept in vitro not only serine, but also, to some extent, leucine. Nucleotide replacement experiments indicated that m1G37 is critical for leucylation activity. This finding… CONTINUE READING